GI-safe aspirin leads PLx’s pipeline of improved safety NSAIDs

As we discussed in class, aspirin can have detrimental effects on the lining of your stomach when taken frequently.  However, a new wave of Aspirin has been developed that does not have these same side effects; "clinical studies have demonstrated that PL220, designed to deliver aspirin’s anti platelet effect without its GI toxicity, is as effective as regular aspirin and reduced ulcers by 75 percent".  The breakthrough was in the development of a "constant barrier" so that NSAIDs do not bind to phosphatidylcholine in the lining of the GI tract.