This article is a more in-depth conversation on how much your brain has to do with your muscle ability, specifically muscle fatigue. It basically shows how the brain inhibits activity when it feels it's at a certain threshold, where pain or danger might come into effect. This new discovery in the brain's involvement with such things could help to figure out causation and possible solutions for various diseases responsible for muscle fatigue.
http://www.biologynews.net/archives/2011/12/05/how_muscle_fatigue_originates_in_the_head.html
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