F.D.A.’s new reports suspect the bone supplement known as bisphosphonates may have the reverse effect and cause weakening of the bones over time. Bisphosphonates is a drug that is suppose to slow the aging of bones byletting them dissolve slower and rebuild faster. However, women taking bisphosphonates display symptoms of weaker, lower bone density over time, a condition called osteoporosis. Doctors are still unsure of the results concerning bisphosphonates, but they advise to stop using the drug after three to five years of use.
http://well.blogs.nytimes.com/2012/05/09/new-cautions-about-long-term-use-of-bone-drugs/
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